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Ketamine: effects and risks of this drug

This substance is used in medical contexts, but also in a recreational and uncontrolled way.

Throughout history, many substances have been used in medicine as anesthetics and pain relievers. Many of these substances have subsequently been removed from the medical field for recreational use.

One of these substances is ketamine, or “special K”, an element used in medicine and veterinary medicine that is known for its ability to generate dissociated states of consciousness.

 

Ketamine as a psychoactive element

Ketamine is a psychoactive substance initially used in medicine and veterinary medicine (currently its main legal use is in veterinary practice) as a general anesthetic. It is a drug or drug derived from phencyclidine, which has characteristics that make it belong to the group of psychodysleptic substances. As such, it generates an alteration in the functioning of the nervous system that tends to cause perceptual disturbances such as hallucinations.

This drug acts on the nervous system as a substance with depressing characteristics, generating sedation and analgesia effectively by reducing the neuronal activity of the brain.

Also known as Kit-kat drug, it is also consumed recreationally due to its powerful hallucinogenic effects, which are characterized by causing dissociative pictures in which individuals perceive that their mind is separated from their body and even that they are able to observe your body from the outside, just like some near-death experiences.

On the other hand, ketamine is usually applied intravenously at a medical and veterinary level, although recreationally it is usually made as a powder to inhale or as a tablet or pill to consume orally. This substance causes a certain level of amnesia after consumption and is generally odorless and tasteless.

 

Ketamine effects

Ketamine has a wide variety of effects, which you can see below.

1. Physical relaxation

At relatively low doses, the effects of this substance are relaxing and anesthetic. Usually, numbness is noted in different parts of the body, such as the extremities, as well as feelings of placidity.

2. Amplification of sensory perception

Although it is a depressant substance, in its recreational use it has been seen that ketamine generates amplified sensory perception. Colors and sounds look brighter and sound louder. This effect is especially noticeable in the first moments after administration.

3. Alterations of consciousness

Ketamine generates alterations in consciousness that usually cause the subject to be clouded, disoriented, and with loss of time.

4. Hallucinations and K-Hole

K-hole is understood as the dissociative experience generated by the consumption of ketamine in which the user perceives a sensation of floating and leaving the body. This hallucinatory experience can be lived as positive and spiritual or as aversive and terrifying when faced with the feeling that the body is being abandoned (the “bad trip”). Apart from this experience, it can also generate other hallucinations.

5. Amnesia

Ketamine causes powerful amnesia of what happened after its administration, which is why it is used in medical practice as general anesthesia. However, this characteristic together with its sedative action means that the use of ketamine has been linked to several cases of rape.

6. Analgesia

Ketamine administration causes a powerful analgesic effect, which is used at the medicinal and veterinary levels in the different processes in which it is used. However, in its recreational use, there is a risk of committing risky acts with consequences that can be serious due to the absence of perceived pain, such as jumping down the stairs, starting fights, or performing certain types of jumps.

7. Disinhibition

This substance usually provokes a disinhibitory effect on the person who consumes it, which can provoke the performance of acts that generally would not be carried out or stop taking precautions regarding specific behaviors.

8. Lack of coordination and reduced ability to move

Ketamine generates in the individual a state of little coordination capacity regarding movement, which is reduced.

9. Physiological effects

The use of ketamine causes different alterations at the physiological level. It generates bronchodilation and increases the pressure sanguine to and cardiac rhythm. This also usually causes an increase in the level of salivation. It can cause respiratory depression.

Mechanism of action

The mechanism of action through which ketamine affects our nervous system is not yet completely clear, although it is based on its performance as an antagonist of NMDA receptors, blocking the action of glutamate as an excitatory agent of the nervous system. It also influences its interaction with endogenous opiate receptors. Buy Ketamine online.

The dissociative effects seem to be due to the alteration of the functioning of the limbic system while the depression of the thalamic-neocortical connection is generated. It also causes depression of the somatosensory cortex, which partly explains the sensations of analgesia.

Associated risks and side effects

Ketamine use has serious health risks if done uncontrollably, such as when used recreationally. Some of the risks are as follows.

1. Dependency

Ketamine is a highly addictive substance, making it relatively easy to generate tolerance and dependency (especially psychic) ​​towards it.

2. Poisoning

It is not difficult to generate intoxication from the abuse of this substance. The most common symptoms are the presence of anxiety, hallucinatory experiences such as those mentioned above, aggressiveness, seizures, and gastrointestinal disturbances in the form of nausea and vomiting.

3. Cognitive impairment and memory disturbances

As we have said, the consumption of ketamine produces amnesia after consumption. However, this effect seems to be potentiated and remains in the body in the long term if consumption is frequent, given that over time, the destruction of a large number of neurons is caused.

Short-term memory loss is especially visible. Cognitive performance is greatly diminished.

4. Depression

Although in low doses it has antidepressant effects, used continuously over time, and in high doses, this substance can cause depression in the person who consumes it.

5. Anxiety

Long-term consumption of ketamine causes an anxiety-causing effect, especially when withdrawal syndrome occurs.

6. Cardiorespiratory disorders

Another effect of ketamine is the alteration it causes in the cardiorespiratory system. The increase in blood pressure it causes can lead to severe cardiovascular disorders, arrhythmias, and tachycardias. On the other hand, ketamine depresses the respiratory system, which can cause a stop in high doses. It can also lead to cardiorespiratory failure.

7. Destruction of the genitourinary epithelium

Numerous cases of individuals suffering from pain in the genitourinary system derived from the consumption of ketamine have been found. This pain comes from the action of ketamine in the urine, which generates the destruction of the internal epithelial cells of the bladder.

 

New indications

Although it has been used mainly as an anesthetic, various investigations have shown that ketamine seems to have a positive effect in cases of depression, with a quick action when it comes to fighting its symptoms. Apparently, this is because this substance contributes to regenerate the neural connections that depression alters. Buy Ketamine online.

Much more thorough research is needed in this regard since the side effects of this substance can be very serious, but this fact could contribute in the near future to generating new antidepressant drugs that are faster acting than the current ones.

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The Benefits of MDMA

Therapeutic use of MDMA is possible

The MDMA is a drug empatógena the same group as amphetamine, which is effective mainly in the sense of euphoria.

Recently, this drug has seen great advances in research and seems to be consolidating among some scientists the idea that its therapeutic use could be beneficial. In fact, earlier this year, several US government agencies approved clinical trials with this drug for the experimental treatment of Post-Traumatic Stress Disorder and anxiety in patients with a serious or terminal illness.

Although it seems to be a scandalous decision, in reality, modern psychotherapy with the prescription of “psychedelic” drugs probably began in the early 1960s. And it was, precisely, MDMA one of the first to be introduced in Europe for its application in psychological or psychiatric therapies, despite having been initially classified as a dangerous drug of “opening the doors of consciousness”; in a way, it is a true statement since MDMA is an entactogen, which can be interpreted as “that contacts the interior”.

Some research has already suggested that this psychoactive could be of great help in psychological and psychiatric therapy offices alike since it has generally shown that it can make people speak with more passion and forcefulness about their emotions, both positive and negative. As well as a tendency to talk more about the future and death has been observed, perhaps because his ability to make people more introspective is that strong. Buy Mdma online.

For many people who have been able to experience assisted therapies with this drug, the results have been unexpectedly healing.

MDMA recommended for autists with social anxiety

The future looks bright for those who support the use of psychedelic drugs. A few days ago, the world’s first legal MDMA store opened in Amsterdam, the Netherlands; Now a study comes out that claims that MDMA can be used in the treatment of autistic people with social anxiety disorders.

Forget about conventional medicine

The study, conducted by Progress in Neuro-Psychopharmacology & Biological Psychiatry, noted that there was a high level of social fear among adults with autism because they are sensitive to social pressures.

Although it might seem like an unconventional approach, they saw great improvement when using MDMA (also known as XTC) in the treatment of these patients, who used to respond poorly to other types of medications and treatments.

Medicinal MDMA

It is not the first time that research has been conducted on MDMA, for years it has been used in psychiatry. Other patients who have been experimented with this drug are people with post-traumatic stress syndrome.

According to studies, this group has also been able to benefit from the drug.

The origin, love, and euphoria

The German company, Merck, created this drug in 1912 by mistake and it was not used until 1967 when a chemist from the University of California, Alexander Shulgin, rediscovered it. Shulgin is also responsible for amphetamines.

One of the best-known effects of MDMA is its ability to remove inhibitions and provide a feeling of love and euphoria. According to studies, if its use is in small amounts and not on a regular basis, it is not addictive.

 

DEA Approves Use of MDMA for Psychiatric Treatments

Do you remember when we write about the healing effects that MDMA has? Well, apparently, the DEA heard us and the use of ecstasy for psychotherapeutic treatments will soon be available.

In a previous post, we said that MDMA could be used to treat hearing problems and Oprah had made a report on the use of this drug to treat emotional problems, especially in patients with post-traumatic stress and depression.

This time, the Drug Enforcement Administration or DEA released its consent to move forward with the study of the clinical use of MDMA for psychotherapies.

The decision came as a result of a study carried out by the Multidisciplinary Association for Psychedelic Studies, known as MAPS. They found that PTSD patients improved markedly, stopped presenting symptoms, and the effects persisted after treatment.

As always, there are people who oppose MDMA treatment, but in its response, the DEA stated that it would be a delicate treatment in which the patient will not have the drug available, nor will he be able to acquire it outside of therapy.

 

Study reveals that pure MDMA can cure you of diseases

Believe it or not, every time you take an ecstasy pill you are helping your body a little.

Various investigations have determined that the use of MDMA can help cure various ailments and diseases.

First, the University of Oakland conducted research to determine that this drug can be used to cure Tinnitus. This is the sound heard when there is no sound source. The classic beep that sounds after exiting the rave. Buy Mdma online.

The discussion about MDMA started when several people expressed that Tinnitus was leaving after taking a pill at concerts, says Grant Searchfield, a professor at the university.

Second, an article appeared in Oprah Winfrey’s magazine stating that ecstasy can be used to help patients with various psychiatric conditions.

In the article, they affirm that despite being a prohibited substance, in its pure form it does not harm the body and helps people control moods. So it can be applied for disorders such as depression, anxiety, chronic pain, body image disorder, and especially for cases of post-traumatic stress.

The medicinal uses of MDMA have not yet been fully confirmed, but we know that it will bring changes in traditional medicine.

What do you think of the use of ecstasy in medicine?

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What is Heroin? Its uses and effects

Heroin

Other names of Heroin: White lady, Rubber, Tongue, Paste, White powder

Introduction

Heroin is a white or brown powder or a black sticky substance. It is an opioid drug from morphine, a natural substance in the bud of the Asian poppy or opium poppy. It can be mixed with water and injected with a needle. Heroin can also be smoked or inhaled through the nose. All of these forms of heroin use send it to the brain very quickly, making it very addictive.

Regular use of heroin can lead to your tolerance. This means that users need more of the drug to have the same effect. High doses lead to heroin dependence over time. If dependent users stop the drug, they have withdrawal symptoms. These include agitation, muscle and bone pain, diarrhea, vomiting, and “goosebumps” chills. Buy Heroin online.

The main health problems of heroin include miscarriages, heart infections, and death from overdose. People who inject the drug are also at risk for infectious diseases, including HIV / AIDS and hepatitis.

Opiates are substances derived from the opium plant. Interestingly, for many years, these substances have been used to relieve pain. Its effects are analgesic (property of removing pain) and hypnotic (property of producing sleep), as well as euphoric and sedative. Opiates are divided into:

Natural: Opium, morphine and codeine.

Semi synthetics: Heroin.

Synthetics: Methadone, pethidine, and tilidine.

Heroin is a semi-synthetic product derived from morphine. It is not used for medical purposes, so it is only found in restricted places or online. There are two types of heroin: white heroin of higher purity, and brown heroin of lower purity and greater toxicity.

How is heroin used?

Heroin is usually aspirated, injected, inhaled, or smoked. Typically the addict may be injected up to fourfold on a daily basis. While intramuscular injection produces a relatively slow onset of euphoria (5 to 8 minutes), the intravenous injection causes the fastest euphoria surge (7 to 8 seconds) and provides the greatest intensity. Its maximum effects are generally felt after about 10 to 15 minutes when heroin is smoked or inhaled. NIDA researchers have confirmed that all forms of heroin administration cause addiction.

This drug produces two types of effects:

Immediate effects

In a first stage, called in slang ‘honeymoon’, after administration there is a ‘flash’, a very intense sensation of pleasure, and within a few seconds a state of total sedation and a certain euphoria, with the absence of any psychic discomfort and lasting approximately 2-3 hours, gradually disappearing.

On a physical level it produces:

  • Dry mouth
  • Decreased size of the pupils.
  • Intestinal constipation
  • Slowed respiratory rate.
  • High doses cause death from respiratory depression.
Long-term effects

These will depend, as in the rest of the consumptions, on the quantity consumed, the route of administration, hygienic/sanitary aspects related to food, lifestyle, etc. In general, the long-term effects, once tolerance and dependence on the substance have developed are:

  • Nutritional alterations, caused by eating disorders and weight loss.
  • Digestive disturbances; produce constipation.
  • Cardiovascular and blood disorders; Among other effects, anemia appears.
  • Increased risk of abortion, premature delivery, as well as alterations in the newborn.
  • Psychological disturbances: apathy (lack of interest), depression, self-centeredness (being self-centered, need to be the center of attention).
  • Nervous system disorders: attention, memory, and insomnia disorders.
  • Gynecological disorders: with disorders in menstruation and ovulation.

Forms of consumption

In drug addicts, the most widely used drugs in this group are morphine and heroin, parenterally (especially the intravenous route), although currently and as a consequence of AIDS, this route is being displaced by sniffed and smoked consumption. Buy Heroin online.

Opioid withdrawal syndrome (ODS)

First hours after the last consumption: “Craving” (desire to consume), anxiety, drug search.
8 to 15 hours: Tearing, sweating, runny nose, yawning.
16 to 24 hours: Mydriasis, piloerection, muscle cramps, waves of cold and heat, diffuse algae, anorexia, irritability.
Subsequently: Insomnia, fever, motor slowdown, abdominal pain, nausea, vomiting, diarrhea, increased respiratory rate, pulse, and blood pressure.

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