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Cannabis and Parkinson’s disease

 

Parkinson’s disease is the second most common neurodegenerative disease, after Alzheimer’s disease. There is currently no cure for the disease. Could cannabis be useful to protect the brain of these patients or to alleviate their symptoms?

Parkinson’s disease is a chronic degenerative disease of the central nervous system that mainly affects the areas of the brain responsible for controlling movement. It generally appears in people over 60 years old (although there are cases of the so-called juvenile Parkinson that appear in people under 40 years old) and more in men than in women. Buy CBD cigarettes – regular

Parkinson’s disease is defined by the death of neurons in an area of ​​the brain called the substantia nigra, responsible for the production of dopamine, one of the neurotransmitter molecules necessary for signals to travel properly through the brain. This lack of dopamine alters the signaling of that area, the basal ganglia, in charge of movement control. That is why the main symptoms of the disease are motor. To the characteristic tremor at rest, which everyone associates with the disease, we must add rigidity, postural instability and bradykinesia (slowing down of movements). Sensory, sleep, affective problems (depression or anxiety) and, in the later stages, dementia may also appear in later stages of the disease.

In approximately 5% of cases, the disease appears as a consequence of mutation in certain genes. However, in the vast majority of patients the cause is unknown, probably being a mixture of genetic susceptibility and environmental factors.

Currently, there is no cure for the disease and only its symptoms are treated. In addition, one of the main treatments, levodopa, which is used to supply dopamine deficiency, ceases to be useful after a few years and causes uncontrolled movements (dyskinesias) in patients. This makes it necessary to investigate new compounds that can protect neurons from death caused by this disease and / or alleviate its symptoms. Buy CBD cigarettes – menthol online

Against this background, could cannabis be useful in the treatment of Parkinson’s disease? Already in the late 19th century, the use of cannabis for the treatment of Parkinson’s disease was described for the first time in Europe by William Richard Gowers in his “Manual of Diseases of the Nervous System”. Philadelphia, Pa, USA: P. Blakiston’s Son & Co; 1888). Let’s see what the scientific evidence is 130 years later.

Cannabis compounds called cannabinoids (of which more than 100 have been described) act in our brain by binding to structures called the CB1 receptor, mainly present in neurons and responsible for the psychoactive effect of some of these cannabinoids, and CB2 receptor, present mainly in glial cells, responsible among other things for the inflammatory response. These receptors, together with the endogenous molecules that activate them (endocannabinoids) are part of the endocannabinoid system, an intercellular communication system present in our body. Buy CBD flower online

Many of the cannabinoids have great neuroprotective potential. By binding to the CB1 receptor in neurons, they can protect them from various harmful stimuli. They also have the anti-inflammatory capacity, mediated by the binding to the CB2 receptor of glial cells. And last but not least, cannabinoids are important antioxidant compounds, protecting neurons from damage caused by oxidative stress (very important in Parkinson’s disease) independently of their receptor binding, due to their own molecular structure. , or by binding to other non-cannabinoid receptors, such as PPAR nuclear receptors that have antioxidant activity. This has been shown in numerous preclinical studies (in vitro and in laboratory animal models) for different diseases such as Alzheimer’s disease,

The basal ganglia area, affected in Parkinson’s disease, has a high density of CB1 cannabinoid receptors, which makes sense since the endocannabinoid system has, among its functions, that of movement control, generally inhibiting it. The importance of the endocannabinoid system in this structure suggested the potential that its manipulation would have in Parkinson’s disease. It has been seen both in experimental animal models and in patients with Parkinson’s disease that this endocannabinoid system is altered in the disease. An increase in the CB1 receptor has been reported in the neurons of the basal ganglia, an increase in the CB2 receptor in the glial cells responsible for inflammation, and an increase in the level of endocannabinoids. This has been interpreted as a response of the organism to the damage caused by the disease. Some have considered the endocannabinoid system as an innate brain defense mechanism. Buy CBD prerolls online

Pharmacological studies carried out in animal models have seen the neuroprotective potential of those compounds with antioxidant capacities, such as Δ9-tetrahydrocannabinol (Δ9-THC, the main psychoactive compound in cannabis), cannabidiol (CBD, the other most important cannabinoid, without psychoactive activity) and Δ9-tetrahydrocannabivarine (Δ9-THCV) and those with anti-inflammatory capacity by binding to the CB2 receptor (such as Δ9-THCV). The activation of the CB1 receptor, although it is a neuroprotective strategy that is used in other diseases, would be contraindicated in the case of Parkinson’s disease since it would worsen the motor symptoms by enhancing the immobility of the patients.

Despite the large accumulated preclinical evidence, clinical research to date has not yielded positive results. Buy marijuana online

Observational studies seem to suggest that cannabis may improve motor symptoms. In some of these studies, patients who used cannabis have indicated that they had experienced an improvement in some of the different symptoms of the disease: tremor at rest, bradykinesia, uncontrolled movements caused by treatment, sleep problems, or pain. There are also studies, however, in which patients did not experience any improvement in tremor after consuming a single dose of smoked cannabis. In another study in which CBD was administered to Parkinson’s patients, they reported improvements in some psychotic symptoms and in their sleep problems. This type of observational study presents numerous problems since researchers cannot control the variables of the experiment, there is no control group with which to compare the effect, the measures are indirectly based on what the patient reports, … all this means that these studies present many variables that can confuse the result. Chief among them is the placebo effect. Patients, aware that they are using cannabis, can report that they feel better by being convinced that this use will make them feel better. Although this is not negligible, of course, it would be desirable to see a “real” effect. This is accomplished by conducting “double-blind” randomized clinical trials in which neither the patient nor the investigator knows whether the patient is taking the treatment or a control substance.

Unfortunately, few randomized, double-blind clinical trials have been conducted with cannabis in Parkinson’s patients, and there are also a few recruited patients. In these few clinical trials, the results have not been promising. Recent studies have seen that using both Δ9-THC isolate and a cannabis extract with Δ9-THC and CBD, no beneficial effects on motor symptoms are observed. Nor have any benefits been reported in quality of life or sleep problems. In another study in which CBD was administered for 6 weeks, no effect was seen on either motor symptoms or neuroprotection, although an improvement in patients’ quality of life was seen. Although these studies have been carried out with few patients, it seems to indicate that cannabis is not beneficial in treating the motor symptoms of the disease, although it could help in treating secondary symptoms. It would be necessary to carry out studies with a larger number of patients and with other types of compounds that have demonstrated their efficacy in preclinical studies, such as Δ9-THCV. For this, a change in the legislation would be necessary to change the current status of cannabis as a drug of abuse in many countries, which would facilitate its use in research. Buy hemp online

In view of these results, it appears that cannabis use, due to its ability to activate the CB1 receptor by compounds such as Δ9-THC and others, would not be the best strategy for the treatment of Parkinson’s disease. However, treatment with those compounds with the best pharmacological profile, such as Δ9-THCV combined with CBD, either in its pure state or as botanical extracts of plants enriched in these compounds, could be useful.

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CategoriesBlog,  Cannabis

9 Best Marijuana Packaging Businesses

If you are in a dispensary, manufacturer, or other cannabis-related business, you should visit the most popular cannabis packaging business.

The cannabis industry has flourished, especially in the United States and Canada, with increasing legalization. But now it’s not just popping up in stores and stores. There are many organizations that help with the needs of the industry such as attorneys, employers, and cannabis packaging firms.

Marijuana packaging companies can help you with everything you need when it comes to packaging your products. Cannabis packaging companies will make sure you get the best quality packaging and can even help you brand your Kana business.

That said, you should check out your company Here are the most popular cannabis packaging companies:

 

Marijuana packaging

MarijuanaPackaging .com is one of the largest and most popular cannabis packaging companies. From the moment you enter your site, you will find all kinds of packaging for gaskets and ink tubes, grocery containers, capsule bottles, evaporative cartridges, and much more.

The company seems to really understand the needs of cannabis companies and covers almost everything you can imagine. In addition to this, they also provide a custom brand. Branding is very important when it comes to your products and when it comes to marketing and credibility, precisely identified packaging can give your business a huge boost.

They don’t just supply cannabis dispensaries. Smoke shops, bedside stores, and stores selling vaping products can benefit greatly from the effective packaging they offer. Everything is affordable and free delivery is ordered for $ 250 and up. This makes it easier for companies to buy all the containers and packages they need in bulk.

Kush Supply Co.

Formerly known as Kush Bottle, Kush Supply Co. is a cannabis packaging company that can meet all your packaging needs. The company has full-service locations in several different states, including California, Washington, Colorado, Nevada, and Massachusetts. Businesses across the state can take advantage of its fast and efficient service.

Kush Supply Co. provides medical and food-grade packaging for cannabis products. They provide high-quality packaging products that are legal as well as environmentally friendly.

Businesses can look for Kush Supply Co.’s wide range of packaging flowers, densities, groceries, pre-rolls, and more packaging that you may need. Whether you need a pop-top bottle or a child-proof bag, you can search for a variety of packaging here. It’s a part of one of the largest packaging companies and Kushco Holdings.

Promotion of Cannabis

When it comes to B2B cannabis packaging, brand lighters, cigarette papers, custom brand products and cannabis promotions for custom packaging are your one-stop-shop.

Cannabis Promotional Products are very easy to order and with fast shipping times, you will definitely get your products quickly and reliably. All of their teams are organization-based and have a national distribution channel so you can meet the deadlines of your brand.

With state-of-the-art systems, you can get free and fast virtual tests directly on the website and even request free samples so you know what you get. If you are looking for a great B2B cannabis packaging and branding business. Then take a look at the cannabis promotions.

FunkSac

Fansack is one of the most popular cannabis packaging companies. Their online store offers legally compatible cannabis packaging that matches cannabis products. Some of their popular offers include cannabis grocery storage and curing bags, lockable twist bags and custom bags.

Companies can contact them for attractive custom packaging for their business. Their products are designed to be child-resistant and keep the products fresh and with the help of a few brands at the top you will end up with high-quality packaging for your business.

Their website is easy to navigate so merchants can buy whatever they need. They also provide a sample package for those who want to evaluate the quality of their packaging. Overall, this is a cannabis packaging company that you can trust.

420 packaging

420 Packaging Provides extensive packaging and labeling for cannabis products. These are a long-lasting company that has a lot of experience in the industry and as such all their products meet top quality and current packaging standards.

They can see the variety of products offered to them directly from their home page. Dispensary and store owners can benefit from essential items such as plastic and glass containers, zip-locked plastic bags, condensed containers, and cigarette paper. They provide state-compliant RX labels for your products, making the entire packaging and labeling process easy and hassle-free.

Their products are child-friendly and follow state laws so you can be sure that everything through its packaging is also legitimate products customizable – many colors and styles available. You can personalize the packaging with your brand. The products are offered at solid prices, especially when you buy in bulk. It is one of the best packaging companies to do all the necessary research on your cannabis.

 

Dymapak

Dimapac is a packaging company that focuses on unique and innovative packaging suitable for cannabis products. Some other packaging companies may not have a range of products, but they do offer a limited range of specific packaging products. Its packaging complies with legal regulations and is certified to guarantee the superior quality of the laboratory.

Their goal is to provide durable, safe, and effective storage bags for marijuana and other medical products. Its packaging is odor-proof and designed to meet the requirements of cannabis packaging.

One of its main offers is Secure Sack, a child-proof bag that will keep marijuana fresh and protected from harm. They also provide Twistspenser packaging for liquid products that is safe, effective, and child-proof. They offer different sizes of packaging and you can also contact them for custom packaging that meets the needs of your business.

Pollen gear

Pollen Gear offers the most attractive and effective packaging options out there. All your products can be personalized with unique images and logos. It’s one of the things that can really make your packaging and still make your business different. Their homepage contains high quality, custom products designed to keep marijuana fresh and safe for kids.

They offer a variety of packaging including stink-proof pop boxes and syllabic Snaptech bags that will keep cannabis products fresh. From there, you can see that they are made for quality and durability, something that can really make a difference for companies and their customers.

Pollen Gear seems to be more focused on premium products. Businesses may spend a bit more but premium packaging helps your business look better and attract more paying customers. Your packaging with specific and strong products is valuable and customization available for any business search.

 

Shutter label

Shutter labels specialize in the cannabis packaging and branding industry. They have a variety of packaging options that can be adapted to all types of marijuana products. Not only do they have solid vials and tubes, but they also provide packagings such as vaping tanks, pre-wound gasket boxes, and syringe packages.

In addition to many packaging products, they can help your company with products and brands. It includes things like snapbacks, pins, and custom stickers. With proper branding, these types of items can help you increase your brand recognition and attract more quality customers.

Shutter labels can even help you design your brand. In fact, they even offer free logo design for 24 245 per order you’re professionally designed marketing materials can be a huge incentive for your business if you’re a cannabis startup. His Brands page shows some of his past work. It’s a great company to look at as well as it’s custom brand packaging and products.

 

N2 packing

N2 packaging systems are a cannabis packaging company with a distinct touch.

They focus on keeping the next level of packaging products fresh. Its nitrogen-packed cannabis packaging products like cannabis flowers can stay strong and fresh throughout the entire storage, delivery, and delivery process. This will ensure that your share price is maintained.

You can see their products on their website and see that their packaging is well made and made with quality materials. These are hermetically sealed, in atmospheric controlled containers that can keep production longer. Once sealed, the packaging is completely odorless and childproof. They follow regulatory requirements to make sure everything is legal and safe for your business.

Their laboratory tests show that their packaging significantly contributed to the durability of a terpene. This means cannabis which retains its taste and strength. Marina companies can take advantage of premium packaging ready for a refreshing look.

These provide customizable products and tools tailored to your business needs. Its packaging is eco-friendly, a major concern for many businesses and customers nowadays.

Conclusion

Its packaging is very important in the sale of cannabis

Delivering products in high-quality packaging can make no difference whether sold or not. Professional packaging companies will also provide packaging that meets state requirements to ensure that your dispensary or store business does not face legal issues.

To make your Canna business success, the most popular cannabis packaging businesses are worth getting the type of packaging your business needs.

Packaging companies can help you with branding. Custom packaging featuring your logo can significantly improve your brand recognition. If you are trying to close your cannabis business, this is one aspect of cannabis marketing that can help you.

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