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Ketamine: effects and risks of this drug

This substance is used in medical contexts, but also in a recreational and uncontrolled way.

Throughout history, many substances have been used in medicine as anesthetics and pain relievers. Many of these substances have subsequently been removed from the medical field for recreational use.

One of these substances is ketamine, or “special K”, an element used in medicine and veterinary medicine that is known for its ability to generate dissociated states of consciousness.


Ketamine as a psychoactive element

Ketamine is a psychoactive substance initially used in medicine and veterinary medicine (currently its main legal use is in veterinary practice) as a general anesthetic. It is a drug or drug derived from phencyclidine, which has characteristics that make it belong to the group of psychodysleptic substances. As such, it generates an alteration in the functioning of the nervous system that tends to cause perceptual disturbances such as hallucinations.

This drug acts on the nervous system as a substance with depressing characteristics, generating sedation and analgesia effectively by reducing the neuronal activity of the brain.

Also known as Kit-kat drug, it is also consumed recreationally due to its powerful hallucinogenic effects, which are characterized by causing dissociative pictures in which individuals perceive that their mind is separated from their body and even that they are able to observe your body from the outside, just like some near-death experiences.

On the other hand, ketamine is usually applied intravenously at a medical and veterinary level, although recreationally it is usually made as a powder to inhale or as a tablet or pill to consume orally. This substance causes a certain level of amnesia after consumption and is generally odorless and tasteless.


Ketamine effects

Ketamine has a wide variety of effects, which you can see below.

1. Physical relaxation

At relatively low doses, the effects of this substance are relaxing and anesthetic. Usually, numbness is noted in different parts of the body, such as the extremities, as well as feelings of placidity.

2. Amplification of sensory perception

Although it is a depressant substance, in its recreational use it has been seen that ketamine generates amplified sensory perception. Colors and sounds look brighter and sound louder. This effect is especially noticeable in the first moments after administration.

3. Alterations of consciousness

Ketamine generates alterations in consciousness that usually cause the subject to be clouded, disoriented, and with loss of time.

4. Hallucinations and K-Hole

K-hole is understood as the dissociative experience generated by the consumption of ketamine in which the user perceives a sensation of floating and leaving the body. This hallucinatory experience can be lived as positive and spiritual or as aversive and terrifying when faced with the feeling that the body is being abandoned (the “bad trip”). Apart from this experience, it can also generate other hallucinations.

5. Amnesia

Ketamine causes powerful amnesia of what happened after its administration, which is why it is used in medical practice as general anesthesia. However, this characteristic together with its sedative action means that the use of ketamine has been linked to several cases of rape.

6. Analgesia

Ketamine administration causes a powerful analgesic effect, which is used at the medicinal and veterinary levels in the different processes in which it is used. However, in its recreational use, there is a risk of committing risky acts with consequences that can be serious due to the absence of perceived pain, such as jumping down the stairs, starting fights, or performing certain types of jumps.

7. Disinhibition

This substance usually provokes a disinhibitory effect on the person who consumes it, which can provoke the performance of acts that generally would not be carried out or stop taking precautions regarding specific behaviors.

8. Lack of coordination and reduced ability to move

Ketamine generates in the individual a state of little coordination capacity regarding movement, which is reduced.

9. Physiological effects

The use of ketamine causes different alterations at the physiological level. It generates bronchodilation and increases the pressure sanguine to and cardiac rhythm. This also usually causes an increase in the level of salivation. It can cause respiratory depression.

Mechanism of action

The mechanism of action through which ketamine affects our nervous system is not yet completely clear, although it is based on its performance as an antagonist of NMDA receptors, blocking the action of glutamate as an excitatory agent of the nervous system. It also influences its interaction with endogenous opiate receptors. Buy Ketamine online.

The dissociative effects seem to be due to the alteration of the functioning of the limbic system while the depression of the thalamic-neocortical connection is generated. It also causes depression of the somatosensory cortex, which partly explains the sensations of analgesia.

Associated risks and side effects

Ketamine use has serious health risks if done uncontrollably, such as when used recreationally. Some of the risks are as follows.

1. Dependency

Ketamine is a highly addictive substance, making it relatively easy to generate tolerance and dependency (especially psychic) ​​towards it.

2. Poisoning

It is not difficult to generate intoxication from the abuse of this substance. The most common symptoms are the presence of anxiety, hallucinatory experiences such as those mentioned above, aggressiveness, seizures, and gastrointestinal disturbances in the form of nausea and vomiting.

3. Cognitive impairment and memory disturbances

As we have said, the consumption of ketamine produces amnesia after consumption. However, this effect seems to be potentiated and remains in the body in the long term if consumption is frequent, given that over time, the destruction of a large number of neurons is caused.

Short-term memory loss is especially visible. Cognitive performance is greatly diminished.

4. Depression

Although in low doses it has antidepressant effects, used continuously over time, and in high doses, this substance can cause depression in the person who consumes it.

5. Anxiety

Long-term consumption of ketamine causes an anxiety-causing effect, especially when withdrawal syndrome occurs.

6. Cardiorespiratory disorders

Another effect of ketamine is the alteration it causes in the cardiorespiratory system. The increase in blood pressure it causes can lead to severe cardiovascular disorders, arrhythmias, and tachycardias. On the other hand, ketamine depresses the respiratory system, which can cause a stop in high doses. It can also lead to cardiorespiratory failure.

7. Destruction of the genitourinary epithelium

Numerous cases of individuals suffering from pain in the genitourinary system derived from the consumption of ketamine have been found. This pain comes from the action of ketamine in the urine, which generates the destruction of the internal epithelial cells of the bladder.


New indications

Although it has been used mainly as an anesthetic, various investigations have shown that ketamine seems to have a positive effect in cases of depression, with a quick action when it comes to fighting its symptoms. Apparently, this is because this substance contributes to regenerate the neural connections that depression alters. Buy Ketamine online.

Much more thorough research is needed in this regard since the side effects of this substance can be very serious, but this fact could contribute in the near future to generating new antidepressant drugs that are faster acting than the current ones.

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